The Locusts and the Drones from Gears of Wars would highly likely be immune to the The Last of Us Cordyceps virus.
The Locust are genetically engineered bio-weapons, making their anatomy a blend of human and subterranean Reptilian creature DNA, Not Human, The Cordyceps Constraint In The Last of Us, the Cordyceps Brain Infection (CBI) is a mutated fungus that specifically targets humans (and in some real-world variations, specific insects).
The Locust Drones Physiology are not mutated humans; they are a unique, subterranean species bred from a mix of human DNA and indigenous Hollow creatures Stemming from the Imulsion-exposed miners at the New Hope Facility.
Visually and physiologically, they possess thick, scaly, reptilian-like hides and cold-blooded traits. The fungus would likely lack the specific chemical receptors needed to bond with a completely different species' nervous system.
Genetic Resilience and Imulsion Exposure, The Light mass/Imulsion Factor The Locust spent generations living in the Hollow, deeply exposed to Imulsion (a highly volatile, parasitic fluid). Their bodies adapted to tolerate an incredibly aggressive, mutagenic substance that alters cellular structures.
They have Hyper-Aggressive Immune Systems, Because their biology is durable enough to withstand the ambient radiation and cellular degradation of Imulsion.
a standard terrestrial fungus like Cordyceps would have a very difficult time bypassing their natural immune defences.
Their Subterranean Adaptations & Fungal Resistance, Living deep underground in dark, damp, cavernous environments means the Locust constantly share space with real Hollow fungi, Molds, and spores.
Evolutionarily, their respiratory systems and skin barriers would be highly adapted to repel or destroy invasive fungal spores to survive in the Hollow.
Genetic Anatomy and Sexual Traits
the origins of the Locust (who mutated from human children exposed to Imulsion, cross-bred with indigenous Hollow creatures under Niles Samson's direction).
Despite their heavily mutated, scaled, and subterranean physiology, Locust Drones (including high-tier leaders like Vraahk, RAAM, and Skorge) are genetically and structurally male. They retain the primary sexual characteristics, hormones, and anatomical structures matching human males. Therefore Vraahk possesses male anatomical traits, those traits are utilized strictly for brutal procreation Rituals to expand the Locust's population.
So He'd be good to go with Ellie and would not be affected during unprotected sex with her in their upcoming AI Hyper Realistic AI Scenes soon